Monitor Closely (1)mitotane decreases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Mitotane is actually a strong inducer of cytochrome P-4503A4; observe when coadministered with CYP3A4 substrates for probable dosage adjustments.Due to long-performing metabolite, not regarded as a drug of